Peer-reviewed veterinary case report
Signs and outcomes of canine skin T-cell lymphoma
By M. Dettwiler et al.·Published in Veterinary Pathology-Supplement·2022·View original on Semantic Scholar →
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Original publication title: Prognostic clinical and histopathological features of canine cutaneous epitheliotropic T-cell lymphoma
- Species:
- dog
Plain-English summary
A 10-year-old female dog with cutaneous epitheliotropic T-cell lymphoma (a type of skin cancer) showed symptoms like red, crusty, and scaly skin. The study looked at 176 dogs and found that those treated with chemotherapy or prednisone lived significantly longer than those who only received supportive care. The average survival time was about 95 days, but dogs receiving treatment had a much better chance of living longer. Key factors that indicated a poorer outcome included severe skin involvement and certain histopathological features.
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Abstract
Canine cutaneous epitheliotropic T-cell lymphoma is a neoplasm with heterogeneous clinical and histopathological presentations. Survival times and responses to therapy are variable, and indicators to predict outcomes are lacking. Clinical and histopathological parameters from 176 archival cases from the University of Pennsylvania and University of Bern (2012–2018) were investigated for associations with clinical outcomes. Histopathological evaluation used digitized whole slide images and QuPath software. Cases included 107 female and 69 male dogs from 48 breeds, with a mean age of 10.4 years. Most common clinical signs were erythema (n = 131), crusting (n = 108), and scaling (n = 102). Affected sites were haired skin (n = 159), lip (n = 74), nasal planum (n = 49), and paw pads (n = 48). The median survival time (MST) was 95 days (1–850). Dogs had 4.26-fold and 2.82-fold longer MST when treated with chemotherapy and prednisone, respectively, than when receiving supportive care. Haired skin involvement (hazard ratio [HR]: 2.039, 95% confidence interval [CI]: 1.180–3.523), erosions/ulcers (HR: 1.871, 95% CI: 1.373–2.548), nodules (HR: 1.496, 95% CI: 1.056–2.118), and crusting (HR: 1.454, 95% CI: 1.061–1.994) were clinical parameters predicting poor outcomes, whereas complete posttherapeutic clinical remission (HR: 0.469, 95% CI: 0.324–0.680) and a stable disease (HR: 0.323, 95% CI: 0.229–0.456) were associated with longer survival. Histopathological features associated with the increased risk of death were extensive infiltration of the panniculus (HR: 2.865, 95% CI: 1.565-4.809), mitotic count ≥7/high-power field (HR: 3.027, 95% CI: 2.065–4.439), cell diameter ≥10.0 µm (HR: 2.078, 95% CI: 1.281–3.372), and nuclear diameter ≥8.3 µm (HR: 3.787, 95% CI: 1.647–8.707).
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/36541607