Peer-reviewed veterinary case report
Prognostic factors affecting survival in dogs with protein-losing
By Nakashima, K et al.·Published in Veterinary journal (London, England : 1997)·2015·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Prognostic factors in dogs with protein-losing enteropathy.
- Species:
- dog
Plain-English summary
A study looked at 92 dogs diagnosed with protein-losing enteropathy (PLE), a serious condition that causes severe gastrointestinal issues and can lead to a poor outlook. The researchers found that certain factors, like the severity of inflammation in the intestines and specific blood tests, could help predict how long a dog might survive after diagnosis. Dogs with certain types of lymphoma had shorter survival times compared to those with chronic enteritis or intestinal lymphangiectasia. However, dogs that showed improvement in their inflammation and protein levels within 50 days of starting treatment had a better chance of living longer.
People also search for: dog protein-losing enteropathy prognosis · dog inflammatory bowel disease treatment · dog lymphoma survival rates
Abstract
Canine protein-losing enteropathy (PLE) is associated with severe gastrointestinal disorders and has a guarded to poor prognosis although little information is available regarding factors affecting prognosis. The purpose of this study was to identify the prognostic factors for survival of dogs with PLE. Ninety-two dogs diagnosed with PLE from 2006 to 2011 were included in a retrospective cohort study. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Variables recorded at the time of diagnosis were statistically analysed for possible prognostic factors in a univariate and multivariate Cox proportional hazard model. In the multivariate analysis, the predictors for mortality in dogs with PLE were more highly scored in terms of canine inflammatory bowel disease activity index (CIBDAI) (P = 0.0003), clonal rearrangement of lymphocyte antigen receptor genes (P = 0.003), and elevation of blood urea nitrogen (BUN) (P = 0.03). Using histopathological diagnosis, both small- and large-cell lymphomas were associated with significantly shorter survival times than chronic enteritis (CE) and intestinal lymphangiectasia (IL). Normalization of CIBDAI and plasma albumin concentration within 50 days of initial treatment was associated with a longer survival time. In conclusion, CIBDAI, clonal rearrangement of lymphocyte antigen receptor genes, histopathological diagnosis, and response to initial treatments would be valuable in separating the underlying causes and could be important in predicting prognosis in dogs with PLE.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26025135/