Peer-reviewed veterinary case report
Blood and electrolyte tests to predict parvovirus survival in puppies
By Paul, Babul Rudra et al.·Published in Topics in companion animal medicine·2023·ICAR-Indian Veterinary Research Institute, India·View original on PubMed →
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Original publication title: Prognostic Potential of Thrombocyte Indices, Acute Phase Proteins, Electrolytes and Acid-Base Markers in Canine Parvovirus Infected Dogs With Systemic Inflammatory Response Syndrome.
- Species:
- dog
Plain-English summary
A group of puppies with canine parvovirus infection developed severe symptoms and were diagnosed with systemic inflammatory response syndrome (SIRS). The study looked at various blood markers to see which could predict survival chances. It found that higher levels of certain markers like C-reactive protein (CRP) and mean platelet volume (MPV) were linked to a worse outcome, while lower levels of albumin and chloride indicated a higher risk of death. The researchers concluded that measuring these markers at the time of admission could help vets determine which puppies might need more aggressive treatment to improve their chances of recovery.
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Abstract
Dogs with canine parvovirus enteritis (CPVE) that develop systemic inflammatory response syndrome (SIRS) frequently have a poor prognosis. The aim of the study was to assess the prognostic potential of thrombocyte indices, acute phase proteins, electrolytes, and acid-base markers in CPVE puppies with SIRS (CPVE-SIRS+) at admission. A case-controlled, prospective, and observational study was performed on 36 CPVE puppies. Mean concentrations of C-reactive protein (CRP), albumin, thrombocyte count, mean platelet volume (MPV), platelet distribution width (PDW), sodium (Na), potassium (K), chloride (Cl) and ionized calcium (iCa) were measured and strong ion difference 3 (SID)Aand Awere determined in CPVE-SIRS+ survivors and nonsurvivors. A prognostic cut-off value for predicting the disease outcome was determined by receiver operating characteristic (ROC) curve analysis. The mean values of MPV, PDW and CRP were significantly higher and the mean values of albumin, Cland Awere significantly lower in CPVE-SIRS+ nonsurvivor than CPVE-SIRS+ survivor puppies on the day of admission, but the thrombocyte count, Na, K, iCa, SIDand Avalues did not differ significantly. The positive predictive values (PPVs) for survival using cut-off value of MPV (≤15.08 fL), PDW (≤14.85%), CRP (≤180.7 mg/L), albumin (≥1.795 g/dL), Cl(≥96.00 mmol/L), and A(≥7.539) were determined as 100%, 100%, 100%, 80%, 100%, and 80%, respectively with better area under ROC curve and sensitivity. Based on sensitivity, specificity, and PPVs from ROC analysis, it is concluded that the determination of Clconcentration and MPV at admission followed by CRP will serve as the most appropriate biomarkers in predicting the disease outcome of CPVE puppies that develop SIRS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37598980/