Peer-reviewed veterinary case report
Ki67 levels predict survival in dogs with large B-cell lymphoma
By Sierra Matiz, Oscar R et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Clinical Veterinary Department, Brazil·View original on PubMed →
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Original publication title: Prognostic significance of Ki67 and its correlation with mitotic index in dogs with diffuse large B-cell lymphoma treated with 19-week CHOP-based protocol.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with diffuse large B-cell lymphoma (DLBCL), the most common type of lymphoma in dogs, were treated with a 19-week chemotherapy protocol that included medications like cyclophosphamide and doxorubicin. Researchers found that dogs with higher levels of a protein called Ki67 had shorter survival times compared to those with lower levels. This suggests that measuring Ki67 could help predict how long a dog might live after treatment. Overall, the study highlights the importance of Ki67 in understanding the prognosis for dogs with this type of cancer.
People also search for: dog lymphoma treatment · diffuse large B-cell lymphoma in dogs · Ki67 levels in dogs with cancer
Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in dogs. We evaluated Ki67 immunoexpression and mitotic index (MI) in dogs diagnosed with DLBCL and treated with a 19-wk CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) protocol. Twenty-nine lymph node samples from dogs diagnosed with DLBCL were analyzed for Ki67 immunostaining, and positive cells present in 1 cmwere counted in a grid reticle for comparison of survival times above and below the means. The Ki67 mean was 107, and the MI mean was 21. There was a significant ( p < 0.05) difference in median survival time between Ki67 immunostaining above and below the mean, with no difference in MI groups. Ki67 values >107 positive cells per 5 HPF counted in a grid reticle were associated with shorter survival times in dogs with DLBCL treated with a 19-wk CHOP-based protocol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29192554/