Peer-reviewed veterinary case report
Ki67 levels predict survival in dogs with high-grade B-cell lymphoma
By Poggi, A et al.·Published in Veterinary and comparative oncology·2017·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: Prognostic significance of Ki67 evaluated by flow cytometry in dogs with high-grade B-cell lymphoma.
- Species:
- dog
Plain-English summary
A study looked at 40 dogs with high-grade B-cell lymphoma, a type of cancer, to see how a specific marker called Ki67 could help predict their survival. The dogs were treated with a standard chemotherapy protocol, and it was found that those with a moderate level of Ki67 had a longer survival time compared to those with low or high levels. Specifically, dogs with intermediate Ki67 levels lived an average of 866 days without the cancer returning, while those with low levels lived only about 42 days. This suggests that measuring Ki67 can help veterinarians better understand a dog's prognosis and tailor treatment plans accordingly.
People also search for: dog lymphoma prognosis · Ki67 in dogs cancer · high-grade B-cell lymphoma treatment
Abstract
Ki67 can discriminate between high- and low-grade canine lymphomas, but its prognostic role in specific subtypes of the neoplasm is unknown. We assessed the prognostic significance of Ki67% (percentage of Ki67-positive cells), evaluated by flow cytometry, in 40 dogs with high-grade B-cell lymphoma, treated with a modified Wisconsin-Madison protocol (UW-25). The following variables were investigated for association with lymphoma specific survival (LSS) and relapse free interval (RFI): Ki67%, breed, sex, age, stage, substage, complete remission (CR). By multivariate analysis, Ki67% (P = 0.009) and achievement of CR (P = 0.001) were independent prognostic factors for LSS. Dogs with intermediate Ki67% (20.1-40%) presented longer LSS and RFI (median = 866 and 428 days, respectively) than dogs with low (median = 42 days, P < 0.001; median = 159 days, P = 0.014) or high (median = 173 days, P = 0.038; median = 100 days, P = 0.126) values. Determination of Ki67 is a prognostic tool that improves the clinical usefulness of flow cytometric analysis in canine high-grade B-cell lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26792094/