Peer-reviewed veterinary case report
AgNOR staining does not predict survival in cats with intestinal
By Rassnick, K M et al.·Published in Journal of veterinary internal medicine·1999·The Donaldson-Atwood Cancer Clinic, United States·View original on PubMed →
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Original publication title: Prognostic value of argyrophilic nucleolar organizer region (AgNOR) staining in feline intestinal lymphoma.
- Species:
- cat
Plain-English summary
A group of 31 cats with intestinal lymphoma were treated with a combination chemotherapy protocol to see how well they would respond. Most of the cats (87%) showed a positive response to the treatment, with an average remission lasting about 120 days and overall survival time of around 201 days. However, the study found that measuring certain proteins (AgNORs) in the cells did not help predict how well the cats would do after treatment. This means that while chemotherapy was effective, the AgNOR test isn't useful for determining prognosis in these cases.
People also search for: cat lymphoma treatment · feline chemotherapy response · intestinal lymphoma prognosis in cats
Abstract
Limited information is available on prognostic factors for cats with lymphoma. The quantity of argyrophilic nucleolar organizer region (AgNOR) proteins can be used as a measurement of cellular proliferative activity. To determine if AgNORs were of prognostic value for feline intestinal lymphoma, the silver staining technique was performed on paraffin-embedded sections of 31 cases. Mean number of AgNORs per nucleus ranged from 1.02 to 4.32. Twenty-four (78%) cats had small AgNORs and 7 (22%) had large AgNORs. All cats were treated identically with a combination chemotherapy protocol. Response to chemotherapy was 87%. Median remission duration and survival times were 120 days and 201 days, respectively. No significant correlation was found between mean number of AgNORs per nucleus or AgNOR size and remission rate, remission duration, or survival time. This study indicates that AgNOR staining is not a useful prognostic factor for cats with intestinal lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10357106/