Peer-reviewed veterinary case report
Lymphocyte levels predict survival in dogs with multi-centric lymphoma
By Mutz, M et al.·Published in Veterinary and comparative oncology·2015·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma.
- Species:
- dog
Plain-English summary
A 7-year-old Labrador was diagnosed with multi-centric lymphoma, a type of cancer that affects the lymph nodes. The dog's treatment involved a chemotherapy protocol, but researchers wanted to see if certain blood tests could predict how well the dog would respond to treatment. They found that the levels of specific white blood cells didn't significantly affect survival rates, but the type of lymphoma did play a role in how long the dog lived without the cancer worsening. More research is needed to understand these blood tests better.
People also search for: dog lymphoma prognosis · Labrador cancer treatment · multi-centric lymphoma in dogs
Abstract
Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi-centric lymphoma. Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre-treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression-free survival (PFS), whereas no variables remained significant for ST. A prospective study of these haematologic variables is warranted to assess their true significance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23786518/