Peer-reviewed veterinary case report
Longer survival in dogs with oral melanoma after surgery and CSPG4
By Piras, L A et al.·Published in Veterinary and comparative oncology·2017·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: Prolongation of survival of dogs with oral malignant melanoma treated by en bloc surgical resection and adjuvant CSPG4-antigen electrovaccination.
- Species:
- dog
Plain-English summary
A group of dogs with oral malignant melanoma (a type of mouth cancer) underwent surgery to remove the tumors, and some received a new treatment called electrovaccination. The dogs that were vaccinated had a much better chance of surviving longer after surgery compared to those that did not receive the vaccine. For example, 73.9% of vaccinated dogs were alive one year later, while only 26.3% of non-vaccinated dogs survived that long. The study suggests that this new vaccination could help improve outcomes for dogs with this serious condition.
People also search for: dog oral melanoma treatment · canine cancer vaccine · dog mouth cancer survival rate
Abstract
Reported post-surgery 1-year survival rate for oral canine malignant melanoma (cMM) is around 30%; novel treatments are needed as the role of adjuvant chemotherapy is unclear. This prospective study regards adjuvant electrovaccination with human chondroitin sulfate proteoglycan-4 (hCSPG4)-encoded plasmid in 23 dogs with resected II/III-staged CSPG4-positive oral cMM compared with 19 dogs with resected only II/III-staged CSPG4-positive oral cMM. Vaccination resulted in 6-, 12-, 18- and 24-month survival rate of 95.6, 73.9, 47.8 and 30.4%, respectively [median survival time (MST) 684 days, range 78-1694, 8 of 23 dogs alive] and 6-, 12-, 18- and 24-month disease-free interval (DFI) rate of 82.6, 47.8, 26.1 and 17.4%, respectively (DFI 477 days, range 50-1694). Non-vaccinated dogs showed 6-, 12-, 18- and 24-month survival rate of 63.2, 26.3, 15.8 and 5.3%, respectively (MST 200 days, range 75-1507, 1 of 19 dogs alive) and 6-, 12-, 18- and 24-month DFI rate of 52.6, 26.3, 10.5 and 5.3%, respectively (DFI 180 days, range 38-1250). Overall survival and DFI of vaccinated dogs was longer in those <20 kg. In vaccinated and non-vaccinated dogs local recurrence rate was 34.8 and 42%, respectively while lung metastatic rate was 39 and 79%, respectively.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27146852/