Peer-reviewed veterinary case report
Kidney injury signs in dogs after heart surgery with bypass
By Starybrat, Daria et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2022·Department of Clinical Science and Services, United Kingdom·View original on PubMed →
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Original publication title: Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.
- Species:
- dog
Plain-English summary
Nineteen dogs undergoing heart surgery with cardiopulmonary bypass were monitored for signs of acute kidney injury (AKI). After surgery, three of the dogs developed AKI, which was identified by a rise in their blood creatinine levels. Researchers found that certain substances in the dogs' blood and urine, like inosine and urinary cystatin B, changed significantly after surgery, suggesting they could help detect kidney issues early. While some dogs showed signs of kidney stress, further research is needed to confirm how useful these markers are in practice.
People also search for: dog kidney injury after surgery · heart surgery dog recovery · acute kidney injury symptoms in dogs
Abstract
OBJECTIVE: To assess the occurrence of acute kidney injury (AKI) in dogs undergoing cardiac surgery under cardiopulmonary bypass (CPB) and explore associations between traditional and novel serum and urinary biomarkers. DESIGN: Prospective cohort study conducted between July 2018 and April 2019. SETTING: University teaching hospital. ANIMALS: Nineteen dogs undergoing cardiac surgery under CPB with preoperative serum creatinine <140 μmol/L (<1.6 mg/dl). INTERVENTIONS: Blood and urine samples were obtained at 4 time points: preoperatively following general anesthesia induction, immediately postoperatively, and 2 and 4 days postoperatively (T, T, T, and T). AKI was defined as an increase in serum creatinine ≥26.4 μmol/L (≥0.3 mg/dl) above baseline within 48 hours. Serum creatinine, C-reactive protein (CRP), symmetric dimethylarginine (SDMA), inosine, beta-aminoisobutyric acid (BAIB), urinary clusterin (uClus), and urinary cystatin B (uCysB) were measured. Data were log-transformed (log) when appropriate and assessed using linear mixed-effects models. MEASUREMENTS AND MAIN RESULTS: AKI occurred in 3 of 19 dogs (15.8%, 95% confidence interval: 0.047-0.384). Inosine increased at T(adjusted mean ± standard error: 53 ± 5.6) in all dogs, and then gradually decreased. LoguCysB increased at T(2.3 ± 0.1) in all dogs and remained high. LogCRP and loguClus increased significantly at T(1.9 ± 0.1 and 3.6 ± 0.1, respectively) in all dogs and remained increased. There was a significant positive association between serum creatinine and SDMA (P < 0.001, estimate ± standard error: 0.06 ± 0.00), between logCRP and loguClus (P < 0.001, 0.35 ± 0.08), between SDMA and creatinine as well as between SDMA and BAIB (P < 0.001, 11.1 ± 0.83 and P < 0.001, 1.06 ± 0.22, respectively) for all dogs at all time points. CONCLUSIONS: Inosine and uCysB concentrations changed in all dogs immediately following a surgery under CPB and may indicate tubular injury. Further studies are required to ascertain the usefulness of those biomarkers in early detection of AKI.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36125401/