Peer-reviewed veterinary case report
Beagle dogs vaccinated with A2 protein show protection
By Fernandes, Ana Paula et al.·Published in Vaccine·2008·Department of Clinical and Toxicological Analysis, Brazil·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein.
- Species:
- dog
Plain-English summary
A group of Beagle dogs was vaccinated with a special protein to see if it could protect them from a serious infection called Leishmania. After being vaccinated, these dogs showed a strong immune response and, importantly, five out of seven of them did not show any symptoms of the disease even 14 months after being exposed to the infection. In contrast, most unvaccinated dogs started showing symptoms within three months. This vaccine not only helped protect the dogs but also made it easier to tell if they were vaccinated or actually infected.
People also search for: Beagle dog Leishmania vaccine · symptoms of Leishmania in dogs · canine vaccine for Leishmania infection
Abstract
In this study, we investigated in dogs the immunogenicity and protective immunity against Leishmania (Leishmania) chagasi infection induced by vaccination with a formulation containing the recombinant A2 protein, an amastigote specific antigen, and saponin. Vaccinated animals produced significantly increased levels of total IgG and IgG2, but not IgG1 anti-A2 antibodies, and remained negative in conventional leishmaniasis serodiagnostic methods. Significantly increased IFN-gamma and low IL-10 levels were detected in vaccinated animals before and after challenge, as compared to control animals. Importantly, while the symptoms onset appeared as early as three months after infection in most control dogs, 14 months after challenge, 5 out of 7 vaccinated dogs remained asymptomatic. Therefore, immunization with rA2 antigen was immunogenic and induced partial protection in dogs, and allowed the serological differentiation between vaccinated and infected animals, an important requirement for a canine visceral leishmaniasis (CVL) vaccine.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18786587/