Peer-reviewed veterinary case report
Proteinuria and enzyme activity in Miniature Schnauzers with high
By Furrow, E et al.·Published in Veterinary journal (London, England : 1997)·2016·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia.
- Species:
- dog
Plain-English summary
A group of Miniature Schnauzers, some with high triglyceride levels (hypertriglyceridemia) and some without, were studied to see if there was a link between high fat levels in the blood and protein in the urine (proteinuria). It was found that 60% of the dogs with high triglycerides had protein in their urine, while none of the dogs without high triglycerides showed this issue. The dogs with high triglycerides also had significantly lower activity of an important enzyme involved in fat metabolism. This suggests that high fat levels in the blood could be causing kidney damage in these dogs.
People also search for: Miniature Schnauzer protein in urine · high triglycerides in dogs · dog kidney problems with high fat
Abstract
Spontaneous hyperlipidemia in rats causes glomerular disease. Idiopathic hypertriglyceridemia (HTG) is prevalent in Miniature Schnauzers, but its relationship with proteinuria is unknown. Decreased activity of major lipid metabolism enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL), may play a role in the cyclic relationship between hyperlipidemia and proteinuria. These enzymes have also not been previously investigated in Miniature Schnauzers. The aims of this study were to determine the relationship between HTG and proteinuria in Miniature Schnauzers and to measure LPL and HL activities in a subset of dogs. Fifty-seven Miniature Schnauzers were recruited (34 with and 23 without HTG). Fasting serum triglyceride concentrations and urine protein-to-creatinine ratios (UPC) were measured in all dogs, and LPL and HL activities were determined in 17 dogs (8 with and 9 without HTG). There was a strong positive correlation between triglyceride concentration and UPC (r = 0.77-0.83, P < 0.001). Proteinuria (UPC ≥ 0.5) was present in 60% of dogs with HTG and absent from all dogs without HTG (P < 0.001). Proteinuric dogs were not azotemic or hypoalbuminemic. Dogs with HTG had a 65% reduction in LPL activity relative to dogs without HTG (P < 0.001); HL activity did not differ. Proteinuria occurs with HTG in Miniature Schnauzers and could be due to lipid-induced glomerular injury. Reduced LPL activity may contribute to the severity of HTG, but further assay validation is required.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27256031/