Peer-reviewed veterinary case report
Protein in urine linked to kidney scarring in Newfoundland dogs
By Koeman, J P et al.·Published in Veterinary pathology·1994·Department of Pathology, Netherlands·View original on PubMed →
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Original publication title: Proteinuria associated with glomerulosclerosis and glomerular collagen formation in three Newfoundland dog littermates.
- Species:
- dog
Plain-English summary
Three Newfoundland puppies, aged 2 months, 2.5 months, and 1 year, were brought in with serious health issues including poor growth, lack of appetite, and signs of kidney problems like protein in their urine. Blood tests showed low protein levels and elevated waste products, indicating their kidneys were not functioning properly. Unfortunately, due to the severe nature of their condition, the veterinarians recommended euthanasia. A postmortem examination revealed significant kidney damage, which was likely caused by a metabolic disease affecting collagen formation in the kidneys.
People also search for: Newfoundland puppy kidney disease · protein in dog urine · dog growth problems · glomerulopathy in dogs · kidney failure symptoms in puppies
Abstract
Three dogs out of a litter of eight Newfoundland dogs developed a progressive fatal glomerulopathy. The affected dogs were a 2-month-old male, a 2.5-month-old female, and a 1-year-old male. The disease in all three animals was characterized by growth retardation, anorexia, proteinuria (14-16 g/liter), hypoalbuminemia (15-21 g/liter, elevated plasma urea (13-28 mmol/liter), and creatinine (83-296 mumol/liter) concentrations. Because of a bad prognosis the dogs were euthanatized. On postmortem examination, the animals had enlarged, slightly pale kidneys, which revealed glomerulosclerosis and glomerulofibrosis on histologic and electron microscopic examination. The lesions consisted of subendothelial and mesangial collagen fibrils and an increase of mesangial matrix. The fibrosis may result from endothelial or mesangial collagen formation as the manifestation of a metabolic disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8203081/