Peer-reviewed veterinary case report
Protocol for transplantation of cells derived from human midbrain organoids into a Parkinson's disease mouse model to restore motor function.
- Journal:
- STAR protocols
- Year:
- 2024
- Authors:
- Fu, Chong-Lei et al.
- Affiliation:
- Institute for Brain Research · China
Abstract
Midbrain organoids provide an innovative cellular source for transplantation therapies of neurodegenerative diseases. Here, we present a protocol for midbrain organoid-derived cell transplantation into a Parkinson's disease mouse model. We describe steps for midbrain organoid generation, single-cell suspension preparation, and cell transplantation. This approach is valuable for studying the efficacy of midbrain organoids as a potential cellular source for restoring motor function. For complete details on the use and execution of this protocol, please refer to Fu et al..
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39120976/