Peer-reviewed veterinary case report
Pseudomonas aeruginosa infection in the hypoventilated middle ear: an experimental model.
- Journal:
- Acta oto-laryngologica
- Year:
- 2005
- Authors:
- Trinidad, Almudena et al.
- Affiliation:
- Department of Otorhinolaryngology · Spain
- Species:
- rodent
Abstract
CONCLUSION: This is a suitable model for studying different aspects of the pathophysiology of chronic suppurative otitis media. OBJECTIVE: To analyze the methodological features of an animal model of chronic suppurative otitis media induced by intratympanic inoculation of Pseudomonas aeruginosa. MATERIAL AND METHODS: Otitis media was induced by inoculation of P. aeruginosa through the inferior aspect of the rat bulla and cauterization of the Eustachian tube via a transpalatal approach. Inspection of the tympanic membrane, culturing of middle ear effusion and processing of the temporal bones for light microscopy were performed. RESULTS: Abnormal otomicroscopic findings and persistence of infection were correlated with the histopathological changes found in middle ear tissues.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15966695/