Peer-reviewed veterinary case report
Exercise intolerance and brain issues in a Sussex spaniel
By Abramson, C J et al.·Published in The Journal of small animal practice·2004·Centre for Small Animal Studies·View original on PubMed →
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Original publication title: Pyruvate dehydrogenase deficiency in a Sussex spaniel.
- Species:
- dog
Plain-English summary
A 2-year-old female Sussex spaniel was brought in because she was having trouble exercising and seemed more tired than usual. Tests showed she had pyruvate dehydrogenase deficiency, a condition that affects how her body processes energy. The vet started her on a special diet for six months, and she didn't get worse during that time. However, after stopping the diet for six months, her exercise intolerance worsened, and she showed signs of central nervous system problems.
People also search for: Sussex spaniel exercise intolerance · dog pyruvate dehydrogenase deficiency treatment · dog dietary therapy for energy issues
Abstract
A two-year-old, intact female Sussex spaniel was presented with signs of exercise intolerance. Pre- and post-exercise serum lactate and pyruvate concentrations and urinary organic acid screening supported a diagnosis of pyruvate dehydrogenase deficiency, as previously reported in this breed. Dietary therapy was initiated for six months, during which time there was no reported clinical deterioration. A full neurological examination and repeat evaluation of lactate and pyruvate concentrations before and after exercise was conducted one year after diagnosis, at which time the patient had been without dietary modification for six months and had developed more severe exercise intolerance along with evidence of central nervous system dysfunction.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15049576/