Peer-reviewed veterinary case report
Comparing imaging methods to measure bone cancer size in dogs
By Cruz, Robert et al.·Published in Journal of the American Animal Hospital Association·2011·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Radiography, 99mTc-HDP, and 111In labeled vitamin B12 SPECT of canine osteosarcoma: a comparative study.
- Species:
- dog
Plain-English summary
A group of 10 dogs with osteosarcoma, a type of bone cancer, were examined using different imaging techniques to measure the size of their tumors. The dogs had tumors in various bones, including the radius and humerus. Researchers found that the bone scan using technetium-99m (99mTc) provided the most accurate size estimates compared to traditional X-rays and other imaging methods. This means that for dogs with osteosarcoma, a 99mTc bone scan can be a helpful tool for veterinarians to assess the extent of the disease.
People also search for: dog osteosarcoma treatment · how to measure tumor size in dogs · bone cancer in dogs imaging options
Abstract
The objective of this article was to compare radiography, planar bone scintigraphy, and single-photon emission computed tomography (SPECT) to determine the size of osteosarcomas in long bones of dogs. Ten dogs with osteosarcoma in six radii, two humeri, one tibia, and one ulna were evaluated. Macroslides, mediolateral radiographs, planar scintigrams, and sagittal images from SPECT scans were used to obtain measurements. On the scintigraphic images, the edges of the tumor were established using the activity profile imaging tool. The radiographic magnification was factored. The mean percentage of tumor size overestimation was 9.29% on mediolateral radiographs, 5.35% on planar scintigrams, and 33.25% on SPECT images. The correlation coefficient adjusted for sample size was significantly higher (P<0.01) for technetium 99m ((99m)Tc) hydroxyethylene diphosphonate (HDP) (75.5%) and radiography (61.3%) compared with indium 111-vitamin B(12) (28.3%). The correlation coefficient for (99m)Tc-HDP was higher than that obtained for radiographs; however, statistical difference between the two variables was not demonstrated (P>0.05). (99m)Tc bone scan is a good estimator of intramedullary size of osteosarcoma in long bones when the activity profile tool to determine the margin of the tumor is used.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21673339/