Peer-reviewed veterinary case report
Does giving CBD oil with epilepsy meds reduce seizures in dogs?
By McGrath, Stephanie et al.·Published in Journal of the American Veterinary Medical Association·2019·View original on PubMed →
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Original publication title: Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy.
- Species:
- dog
Plain-English summary
A group of 26 dogs with hard-to-control seizures due to idiopathic epilepsy were given either cannabidiol (CBD) oil or a placebo alongside their regular seizure medications for 12 weeks. The dogs receiving CBD showed a 33% reduction in seizure frequency compared to those on the placebo, although the overall number of dogs experiencing a significant improvement was similar in both groups. Some dogs in the CBD group had mild side effects like ataxia (loss of coordination) and were removed from the study, but no serious behavioral issues were reported. This suggests that while CBD may help reduce seizures, more research is needed to find the right dosage for better results.
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Abstract
OBJECTIVE: To assess the effect of oral cannabidiol (CBD) administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with idiopathic epilepsy. DESIGN: Randomized blinded controlled clinical trial. ANIMALS: 26 client-owned dogs with intractable idiopathic epilepsy. PROCEDURES: Dogs were randomly assigned to a CBD (n = 12) or placebo (14) group. The CBD group received CBD-infused oil (2.5 mg/kg [1.1 mg/lb], PO) twice daily for 12 weeks in addition to existing antiepileptic treatments, and the placebo group received noninfused oil under the same conditions. Seizure activity, adverse effects, and plasma CBD concentrations were compared between groups. RESULTS: 2 dogs in the CBD group developed ataxia and were withdrawn from the study. After other exclusions, 9 dogs in the CBD group and 7 in the placebo group were included in the analysis. Dogs in the CBD group had a significant (median change, 33%) reduction in seizure frequency, compared with the placebo group. However, the proportion of dogs considered responders to treatment (≥ 50% decrease in seizure activity) was similar between groups. Plasma CBD concentrations were correlated with reduction in seizure frequency. Dogs in the CBD group had a significant increase in serum alkaline phosphatase activity. No adverse behavioral effects were reported by owners. CONCLUSIONS AND CLINICAL RELEVANCE: Although a significant reduction in seizure frequency was achieved for dogs in the CBD group, the proportion of responders was similar between groups. Given the correlation between plasma CBD concentration and seizure frequency, additional research is warranted to determine whether a higher dosage of CBD would be effective in reducing seizure activity by ≥ 50%.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31067185/