Peer-reviewed veterinary case report
Enzyme changes in dogs with acute Rangelia vitalii infection
By Costa, Márcio Machado et al.·Published in Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria·2012·Department of Small Animals, Brazil·View original on PubMed →
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Original publication title: Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs.
- Species:
- dog
Plain-English summary
A group of 7 young female dogs, aged 6-12 months, showed increased levels of certain enzymes after being infected with a protozoon called Rangelia vitalii, which can cause anemia. Blood tests revealed that levels of alanine aminotransferase (ALT), creatine kinase (CK), and aspartate aminotransferase (AST) rose significantly during the infection. These changes suggest that the infection affects the dogs' liver and muscle health. Monitoring these enzyme levels can help veterinarians assess the impact of this infection on dogs.
People also search for: dog anemia symptoms · Rangelia vitalii infection treatment · elevated liver enzymes in dogs
Abstract
Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23070434/