Peer-reviewed veterinary case report
Real-Time Bioluminescence Imaging of Nitroreductase in Mouse Model.
- Journal:
- Analytical chemistry
- Year:
- 2016
- Authors:
- Feng, Ping et al.
- Affiliation:
- Institute of Clinical Trials · China
Abstract
Nitroreductase (NTR) is an endogenous reductase overexpressed in hypoxic tumors; however, its precise detection in living cells and animals remains a considerable challenge. Herein, we developed three reaction-based probes and a related bioluminescence assay for the real-time NTR detection. The high sensitivity and selectivity of probe 3, combined with its remarkable potential of bioluminescence imaging, affords a valuable approach for in vivo imaging of NTR in a tumor model mouse.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27197544/