Peer-reviewed veterinary case report
Using recombinant K28 antigen ELISA to diagnose canine visceral
By Venturin, G L et al.·Published in Parasite immunology·2015·Faculty of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Recombinant K28 antigen in ELISA in the diagnosis of canine visceral leishmaniosis.
- Species:
- dog
Plain-English summary
A study found that a new blood test using a specific protein (recombinant K28 antigen) can accurately diagnose canine visceral leishmaniosis (a serious disease caused by a parasite) in dogs. Researchers tested blood samples from both healthy dogs and those confirmed to have the disease. The new test showed perfect results, correctly identifying all cases of the disease without any false positives. This means that the rK28 antigen test could be a reliable option for veterinarians to diagnose this condition in dogs.
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Abstract
Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area and 80 blood samples from an endemic area for dogs with visceral leishmaniosis (VL), confirmed with positive parasitological tests for Leishmania spp., were used in an ELISA. The parasitological diagnosis was chosen as a gold standard. The ELISA with rK28 antigen showed sensitivity of 100% and specificity of 100%, high agreement with CTA and rK39, indicating that the rK28 antigen is useful for ELISA serological diagnosis of CVL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26408410/