Peer-reviewed veterinary case report
Rectal lymphoma in 11 dogs treated with surgery and chemo
By Van den Steen, N et al.·Published in The Journal of small animal practice·2012·Centre for Small Animal Studies·View original on PubMed →
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Original publication title: Rectal lymphoma in 11 dogs: a retrospective study.
- Species:
- dog
Plain-English summary
An 11-year-old mixed breed dog was diagnosed with rectal lymphoma after a biopsy. Treatment varied among the dogs in the study, but those that received chemotherapy lived much longer than those that did not. The dogs treated with chemotherapy had a mean survival time of about 4.5 years, while those that weren't treated lived only about 2 months. The findings suggest that rectal lymphoma in dogs can have a good prognosis, especially with appropriate treatment.
People also search for: dog rectal lymphoma treatment · lymphoma symptoms in dogs · dog chemotherapy survival rate
Abstract
OBJECTIVES: To retrospectively evaluate the clinical behaviour and immunophenotype of lymphoma of the rectum in dogs. METHODS: Eleven dogs diagnosed with lymphoma of the rectum on histopathology were retrospectively reviewed. Immunohistochemistry with CD3 and CD79a antibodies was performed at diagnosis or retrospectively. RESULTS: Treatment protocol varied with six dogs undergoing surgery and adjuvant chemotherapy, two received chemotherapy after only incisional biopsy, one had surgical resection only, one was treated symptomatically and one dog was not treated. Chemotherapy treatment consisted of either a -low-dose COP (cyclophosphamide - prednisolone - vincristine) protocol (four dogs) or a six-week CHOP-based (cyclophosphamide - vincristine - -prednisolone - anthracycline) protocol (four dogs). Dogs that received chemotherapy lived significantly longer than dogs that did not receive chemotherapy (2352 versus 70 days). Median survival time was not reached, and there was an overall mean survival time of 1697 days. Immunohistochemistry was performed in 10 of 11 samples, and was consistent with B-cell -lymphoma in all cases. CLINICAL SIGNIFICANCE: Canine lymphoma of the rectum is associated with a favourable prognosis. Immunohistochemical evaluation of these lesions was consistent with B-cell lymphoma in all cases in which it was examined.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22882127/