Peer-reviewed veterinary case report
How well the University of Wisconsin chemo works for dog lymphoma
By Kaiser, Claire Inderbinen et al.·Published in Journal of the American Animal Hospital Association·2007·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Reevaluation of the University of Wisconsin 2-year protocol for treating canine lymphosarcoma.
- Species:
- dog
Plain-English summary
A group of 96 dogs diagnosed with malignant lymphosarcoma (a type of cancer) were treated using a standard chemotherapy protocol from the University of Wisconsin. The study found that dogs with more advanced cancer stages or high calcium levels in their blood were more likely to have a relapse. While the average time dogs stayed in remission was about 270 days, their overall survival time was only 218 days, which is shorter than what has been seen in the past. This suggests that while the treatment is still commonly used, some dogs may not respond as well as expected.
People also search for: dog lymphosarcoma treatment · canine cancer survival rates · chemotherapy for dogs with lymphoma
Abstract
This retrospective study investigated a population of 96 dogs with newly diagnosed malignant lymphosarcoma that were treated with the commonly used University of Wisconsin-Madison (UW-M) chemotherapy protocol. Pretreatment characteristics were analyzed to determine prognostic factors. Dogs with higher World Health Organization (WHO) stages (including stage IV) and dogs with hypercalcemia were at significantly higher risk of relapse (P=0.018 and P=0.016, respectively). Dose reduction, treatment delays, and prior therapy with cortico-steroids were not associated with clinical outcome. First remission duration of 270 days was similar to historically reported data. Overall survival time of 218 days was much shorter than historical data.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17339285/