Peer-reviewed veterinary case report
How lean body mass affects kidney test results in healthy dogs
By Hall, Jean A et al.·Published in Journal of veterinary internal medicine·2015·Department of Biomedical Sciences·View original on PubMed →
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Original publication title: Relationship between lean body mass and serum renal biomarkers in healthy dogs.
- Species:
- dog
Plain-English summary
A group of 41 healthy Beagles, averaging about 10 years old, were studied to understand how lean body mass affects kidney function markers in dogs. Researchers found that the level of serum creatinine (sCr), a common kidney function test, can be influenced by the dog's lean body mass and age, while another marker called symmetric dimethylarginine (SDMA) was not affected by these factors. This means that sCr might not be the best indicator of kidney health in dogs with lower lean body mass. The study suggests that SDMA could be more reliable for monitoring kidney function, especially when considering changes in diet.
People also search for: dog kidney function tests · Beagle kidney health · how to improve dog lean body mass
Abstract
BACKGROUND: Symmetric dimethylarginine (SDMA) is an accurate and precise biomarker for estimating glomerular filtration rate (GFR) in humans and cats. Serum creatinine (sCr) also correlates with GFR, but has limitations as a biomarker of renal function because nonrenal factors can influence its concentration. HYPOTHESIS: Differences in lean body mass (LBM) influence sCr, but not serum SDMA concentrations. ANIMALS: Forty-one healthy Beagles, mean age 9.9 years (range: 3.1-14.8 years), were studied over a 6 month period. METHODS: Serum biomarkers of renal function were measured prospectively at baseline, and 1, 3, and 6 months. SDMA concentrations were measured by liquid chromatography-mass spectroscopy and sCr concentrations by enzymatic colorimetry. Body composition was determined by dual energy x-ray absorptiometry. RESULTS: LBM (P < .001) and age (P = .006) were significant explanatory variables for sCr concentration (R(2) = 0.38), but not SDMA concentration. Time on food was the only significant explanatory variable for SDMA concentration (R(2) = 0.49). SDMA concentrations decreased across time (P < .001). LBM was affected by sex (males > females; P = .02). Mature adult dogs (<8 years) had greater LBM compared with geriatric dogs (≥8 years; P < .001). CONCLUSION AND CLINICAL IMPORTANCE: sCr concentrations, but not SDMA concentrations, are influenced by LBM, which limits sCr utility as a biomarker for monitoring renal function in dogs with decreased LBM. Reductions in LBM can lower sCr concentration and overestimate GFR. SDMA concentrations, but not sCr concentrations were influenced by time on food. SDMA could have clinical advantages over sCr in monitoring response to nutritional interventions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25913398/