Peer-reviewed veterinary case report
Gut bacteria differences in cats with intestinal inflammation
By Garraway, Kayode et al.·Published in Journal of veterinary internal medicine·2018·Iowa State University·View original on PubMed →
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Original publication title: Relationship of the mucosal microbiota to gastrointestinal inflammation and small cell intestinal lymphoma in cats.
- Species:
- cat
Plain-English summary
A study found that cats with small cell gastrointestinal lymphoma (a type of cancer) had higher levels of certain bacteria in their intestines compared to cats with inflammatory bowel disease (IBD). Specifically, bacteria like Fusobacterium and Bacteroides were more abundant in the intestinal samples of cats with lymphoma. This suggests that changes in gut bacteria might play a role in the development of this type of cancer. While the study highlights a connection, more research is needed to understand how these bacteria might influence cancer progression in cats.
People also search for: cat lymphoma symptoms · cat IBD treatment · why is my cat losing weight · cat gut bacteria and cancer · small cell lymphoma in cats treatment
Abstract
BACKGROUND: The gastrointestinal (GI) microbiota in healthy cats is altered in IBD. Little research has been performed to identify whether specific bacterial groups are associated with small cell GI lymphoma (LSA). HYPOTHESIS: Mucosal bacteria, including Enterobacteriaceae and Fusobacterium spp., are abundant in intestinal biopsies of cats with small cell GI LSA compared to cats with IBD. ANIMALS: Fourteen cats with IBD and 14 cats with small cell GI LSA. METHODS: Retrospective case control study. A search of the medical records was performed to identify cats diagnosed with IBD and with GI LSA. Bacterial groups identified by FISH in GI biopsies were compared between cohorts and correlated to CD11band NF-κB expression. RESULTS: Fusobacterium spp. (median; IQR bacteria/region) were higher in cats with small cell GI LSA in ileal (527; 455.5 - 661.5; P = .046) and colonic (404.5; 328.8 - 455.5; P = .016) adherent mucus, and combined colonic compartments (free mucus, adherent mucus, attaching to epithelium) (8; 0 - 336; P = .017) compared to cats with IBD (ileum: 67; 31.5 - 259; colon: 142.5; 82.3 - 434.5; combined: 3; 0 - 34). Bacteroides spp. were higher in ileal adherent mucus (P = .036) and 3 combined ileal compartments (P = .034) of cats with small cell GI LSA. There were significant correlations between Fusobacterium spp. totals and CD11bcell (P = .009; rs .476) and NF-κB expression (P = .004; rs .523). CONCLUSIONS: The bacterial alterations appreciated might be influential in development of small cell GI LSA, and should drive further studies to elucidate the effects of microbial-mediated inflammation on GI cancer progression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30084202/