Remission of severe familial proteinuria in a Bracco Italiano dog.

Abstract

The objective of this report was to document clinical remission of suspected familial proteinuria in a Bracco Italiano dog. A 4-year-old intact female Bracco Italiano with a familial history of amyloidosis was presented because of unilateral chemosis, polyuria, and polydipsia. Hypoalbuminemia and severe proteinuria were detectedinitial diagnostics. Although no renal histopathologic assessment was done, there was a strong clinical suspicion for renal amyloidosis. The dog was treated with telmisartan and colchicine (in addition to other therapies) for proteinuria and achieved clinical remission > 5 y post-diagnosis. Key clinical message: Telmisartan is an appropriate 1st-line therapy for proteinuric dogs. Favorable long-term outcomes are possible for dogs with severe proteinuria. Prospective studies are warranted to evaluate effects of telmisartan on AA amyloidogenesis.