Peer-reviewed veterinary case report
Kidney disease in cats and dogs compared to humans
By Dadousis C et al.·2024·School of Health Sciences, United Kingdom·View original on Europe PMC →
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Original publication title: Renal Disease in Cats and Dogs-Lessons Learned from Text-Mined Trends in Humans.
Plain-English summary
Chronic kidney disease (CKD) is a serious condition in both cats and dogs that leads to ongoing damage to the kidneys and can cause various health problems. This study looked at how CKD affects pets by comparing information from human studies to better understand the disease in animals. Researchers used a method to analyze a lot of scientific literature to find common signs, tests, and types of pain related to CKD. They noted that while there is less research on pain in pets with CKD, it is becoming increasingly important to consider their quality of life. The findings from this study could help guide future research on kidney disease in cats and dogs.
Abstract
Chronic kidney disease (CKD) is characterised by progressive kidney damage and encompasses a broad range of renal pathologies and aetiologies. In humans, CKD is an increasing global health problem, in particular in the western world, while in cats and dogs, CKD is one of the leading causes of mortality and morbidity. Here, we aimed to develop an enhanced understanding of the knowledge base related to the pathophysiology of renal disease and CKD in cats and dogs. To achieve this, we leveraged a text-mining approach for reviewing trends in the literature and compared the findings to evidence collected from publications related to CKD in humans. Applying a quantitative text-mining technique, we examined data on clinical signs, diseases, clinical and lab methods, cell types, cytokine, and tissue associations (co-occurrences) captured in PubMed biomedical literature. Further, we examined different types of pain within human CKD-related publications, as publications on this topic are sparser in companion animals, but with the growing importance of animal welfare and quality of life, it is an area of interest. Our findings could serve as substance for future research studies. The systematic automated review of relevant literature, along with comparative analysis, has the potential to summarise scientific evidence and trends in a quick, easy, and cost-effective way. Using this approach, we identified targeted and novel areas of investigation for renal disease in cats and dogs.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/39682316