Peer-reviewed veterinary case report
Protein loss in urine of 14-month-old Bernese mountain dog
By Raila, J et al.·Published in Journal of veterinary medicine. A, Physiology, pathology, clinical medicine·2007·Institute of Nutritional Science, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Renal pathology and urinary protein excretion in a 14-month-old Bernese mountain dog with chronic renal failure.
- Species:
- dog
Plain-English summary
A 14-month-old female Bernese mountain dog was diagnosed with chronic kidney failure, which can cause symptoms like increased thirst and urination. Tests showed that her kidneys had severe damage, including inflammation and scarring, which affected their ability to filter proteins properly. The presence of certain proteins in her urine indicated significant kidney dysfunction. Unfortunately, this condition can be serious, and while specific treatments were not detailed, managing kidney failure often involves dietary changes and medications to support kidney function.
People also search for: Bernese mountain dog kidney failure symptoms · chronic renal failure treatment for dogs · dog urine protein levels
Abstract
The renal pathology and urinary protein pattern of a 14-month-old female Bernese mountain dog with chronic renal failure was investigated. Sodium dodecyl sulphate-polyacrylamid gel electrophoresis and subsequent Western blot analysis of urine showed the presence of heavy and light chains of immunoglobulin, transferrin, albumin, vitamin D-binding protein, transthyretin and retinol-binding protein (RBP), but no excretion of Tamm-Horsfall protein (THP). Histopathological examinations of the kidneys revealed severe membranous glomerulonephritis accompanied by tubular dilatation, tubular atrophy and interstitial fibrosis. The renal expression of megalin, the main endocytic receptor for the re-uptake of proteins in proximal tubules, RBP and THP was reduced or completely absent, indicating severe tubular dysfunction. The identified urinary proteins may be of interest as additional markers for the diagnosis of juvenile nephropathy in Bernese mountain dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17381676/