Peer-reviewed veterinary case report
Best rescue chemotherapy for dogs with resistant B cell lymphoma
By Cannon, Claire Marie & Bennett, Peter·Published in Veterinary and Comparative Oncology·2026·Melbourne Veterinary School, Faculty of Science The University of Melbourne Parkville Victoria Australia, Australia·View original on Crossref →
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Original publication title: Rescue Protocols for Canine Non‐Indolent B Cell Lymphoma: A Systematic Review
- Species:
- dog
Plain-English summary
A 7-year-old dog with non-indolent B cell lymphoma that didn't respond to initial chemotherapy was evaluated for alternative treatment options. While standard multi-agent chemotherapy (CHOP) usually works well, some dogs can become resistant to it, and the best follow-up treatments are not well established. Unfortunately, this review found that there isn't enough information on effective rescue chemotherapy protocols for dogs in this situation. Pet owners should discuss with their veterinarian about the latest treatment options and any new protocols that may be available for dogs with lymphoma that do not respond to initial therapies.
People also search for: dog lymphoma treatment options · rescue chemotherapy for dogs · non-indolent B cell lymphoma in dogs
Abstract
ABSTRACT Canine lymphoma is a heterogenous group of diseases. The most common subtype is diffuse large B cell lymphoma (DLBCL), though definitive diagnosis beyond non‐indolent = multicentric B cell lymphoma is not often achieved in clinical practice as it requires histopathology. Most dogs respond well to standard‐of‐care multiagent chemotherapy (CHOP) but relapse and eventual CHOP‐resistance is likely. Less commonly there is a lack of complete response to initial CHOP treatment. CHOP‐resistant cases are treated with rescue chemotherapy protocols, of which many are published, but the most effective is unknown. In this systematic review we aimed to determine the most effective rescue chemotherapy protocol for dogs with multicentric non‐indolent B cell lymphoma resistant to initial chemotherapy with a CHOP‐based protocol. After initial screening, 65 full‐text articles were reviewed. However, outcomes for the population of interest could not be identified in any, leaving our research question unanswered. Future publications of rescue treatment for canine lymphoma should report outcomes separately for groups of dogs where disease characteristics and prior treatment may affect outcome.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.70048