Peer-reviewed veterinary case report
Dog with breathing failure after moxidectin poisoning recovers
By Beal, M W et al.·Published in Journal of the American Veterinary Medical Association·1999·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Respiratory failure attributable to moxidectin intoxication in a dog.
- Species:
- dog
Plain-English summary
A 5-month-old male Collie was brought to the vet after accidentally eating a deworming medication containing moxidectin, which caused him to become comatose and stop breathing. He had been getting progressively more lethargic and had seizures before the emergency visit. The vet treated him with special breathing support, activated charcoal to help absorb the toxin, and provided nutrients through a tube. After six days on a ventilator, he was able to breathe on his own and was sent home ten days later. A follow-up exam showed he was back to normal, but it’s important to note that some Collies may be more sensitive to moxidectin.
People also search for: Collie moxidectin poisoning · dog respiratory failure treatment · puppy seizure after medication
Abstract
A 5-month-old 22-kg (48.4-lb) sexually intact male Collie was examined after ingesting a moxidectin-containing deworming medication. The dog was comatose and had respiratory arrest after progressively worsening lethargy, ataxia, and seizures. Exposure was confirmed by isolation of moxidectin from a biopsy specimen of adipose tissue, using liquid chromatography-mass spectroscopy methods. Treatment included use of intermittent positive-pressure ventilation, activated charcoal and cathartic administered enterally, nutrients administered via nasogastric tube, and intensive supportive care. The dog was weaned from a ventilator on day 6 after ingestion and was discharged on day 10. The dog was considered clinically normal during examination 24 days after ingestion. On the basis of the dog reported here and toxicologic data provided by the manufacturer of the deworming product, some Collies may have increased susceptibility to products containing high doses of moxidectin.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10613213/