Peer-reviewed veterinary case report
Radiation therapy results for dogs with plasma cell tumors
By Elliott, James et al.·Published in Veterinary and comparative oncology·2020·North Carolina State University, United States·View original on PubMed →
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Original publication title: Response and outcome following radiation therapy of macroscopic canine plasma cell tumours.
- Species:
- dog
Plain-English summary
Thirty dogs with plasma cell tumors, which can occur in various areas like the mouth, skin, and bones, were treated with radiation therapy. Most of the dogs showed improvement, with 95% experiencing either complete or partial responses to the treatment. The median survival time for all dogs was about 697 days, with some living over five years. Dogs receiving more aggressive treatment had better outcomes compared to those treated for comfort. Overall, radiation therapy proved to be an effective option for managing these tumors, leading to significant pain relief and extended survival for many dogs.
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Abstract
Thirty dogs with macroscopic plasma cell tumours (PCTs) were treated with radiation therapy (RT). Twelve patients were treated with palliative-intent prescriptions (range, 4-10 Gy/fraction (median, 7 Gy/fraction) for a total dose of 20 to 35 Gy (median total dose 30 Gy). Eighteen patients received definitive-intent prescriptions (range, 3.0-4.2 Gy/fraction (median, 3 Gy/fraction) for a total dose of 42 to 54 Gy (median total dose 48 Gy). Involved sites included the oral cavity, skin, multiple myeloma (MM)-associated lytic bone lesions, bone (solitary osseous plasmacytoma; SOP), nasal cavity, larynx, retrobulbar space, lymph node and rectum. Ninety-five percent of evaluable dogs had a complete (CR; 16/22) or partial response (PR; 5/22). Patients with MM experienced significant analgesia. The median progression-free survival (PFS) was 611 days (range: 36-2001 days). Events in the non-MM cases included in-field progression (5/26, 19%) and disseminated disease (5/26, 19%). The median survival time (MST) for all dogs was 697 days (range: 71-2075 days), and when only non-MM cases were considered, MST was 771 days (range: 71-2075 days). Fourteen patients were alive without disease progression or had died of unrelated causes. Achievement of a PR was associated with an inferior PFS and MST as compared with CR. Palliative-intent RT was associated with inferior MST as compared with definitive-intent RT. RT is a useful therapeutic modality for PCTs and tumour responses are often complete and durable, with protracted survivals. The optimal radiation dose and schedule are yet to be defined.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32419347/