Peer-reviewed veterinary case report
Response-based CHOP chemo improves survival in dogs with B-cell
By Benjamin, Sarah E et al.·Published in Veterinary and comparative oncology·2021·Department of Clinical Science & Advanced Medicine, United States·View original on PubMed →
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Original publication title: Response-based modification of CHOP chemotherapy for canine B-cell lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with B-cell lymphoma (a type of cancer) was treated with a modified chemotherapy protocol to improve their chances of recovery. The treatment was adjusted based on how well the dogs responded to the initial drugs. Dogs that showed a good response had better survival rates, with some living over a year after treatment, while those who did not respond well had a much shorter survival time. The study found that modifying the treatment based on early response did not increase side effects and helped some dogs live longer.
People also search for: dog lymphoma treatment · B-cell lymphoma in dogs · chemotherapy for dogs with cancer
Abstract
Despite high initial response rates, a subset of dogs with B-cell lymphoma responds less robustly to CHOP-based chemotherapy and experiences shorter survival. One hundred and four dogs with nodal B-cell lymphoma were treated with a response-based CHOP (RBCHOP) protocol modified based on response to individual drugs during the first chemotherapy cycle. Dogs achieving complete (CR) or partial response (PR) at week 3, following treatment with vincristine and cyclophosphamide, received RBCHOP 1 (n = 72), a protocol sequentially rotating vincristine, cyclophosphamide, and doxorubicin. Dogs without a detectable response at week 3 that subsequently achieved CR or PR following treatment with doxorubicin received RBCHOP 2 (n = 14), in which four doses of doxorubicin were given consecutively followed by vincristine and cyclophosphamide. Dogs that failed to respond at week 3 and then to doxorubicin at week 5 assessment were offered rescue chemotherapy (RBCHOP 3, n = 18). Median progression free survival (PFS) and overall survival time (OST) were similar between RBCHOP 1 (PFS 210 days, OST 354 days) and RBCHOP 2 (PFS 220 days, OST 456 days), but significantly shorter for RBCHOP 3 (PFS 34 days, OST 80.5 days, P < 0.001). No presenting signalment nor hematologic variable differentiated patient cohort, however, dogs in RBCHOP 2 and RBCHOP 3 were more likely to have a lymphocytosis at diagnosis (P = 0.02 and 0.04, respectively). Protocol modification based on response during the first cycle resulted in similar toxicity profiles and outcomes to previously published variants of CHOP, and prognosis remained poor for dogs failing to respond during the first treatment cycle.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33729654/