Peer-reviewed veterinary case report
Puppy immune response to modified-live parvovirus vaccine
By O'Brien, S. E. et al.·Published in Journal of the American Veterinary Medical Association·1986·From the Department of Veterinary Clinical Sciences (O'Brien and Hill) and the Department of Microbiology (Roth), College of Veterinary Medicine, Iowa State University, Ames, IA 50011.·View original on Crossref →
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Original publication title: Response of pups to modified-live canine parvovirus component in a combination vaccine
- Species:
- dog
Plain-English summary
A group of 28 puppies were vaccinated against canine parvovirus (cpv) using a combination vaccine every three weeks until they were 11 to 16 weeks old. Most of the puppies that had no prior antibodies developed protective immunity after just one dose of the vaccine. However, some puppies that already had antibodies from their mothers did not respond well to the vaccine, which is a common issue known as vaccination failure. Overall, the study highlights the importance of timing and the presence of maternal antibodies when vaccinating young puppies to ensure they are protected against cpv.
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Abstract
Summary Twenty-eight pups from a general pet population were vaccinated for canine parvovirus (cpv) with a combination vaccine every 3 weeks until the pups were 11 to 16 weeks old. Canine parvovirus antibody titers were measured by serum neutralization before each vaccination and ≥ 2 weeks after the final vaccination. Eighteen pups that initially were seronegative for cpv seroconverted after 1 to 3 doses of modified-live virus cpv vaccine administered when the pups were between 8 and 16 weeks old; 16 of 18 seroconverted after the 1st dose. Of 10 pups that were seropositive for cpv at initial examination, 7 did not develop protective titers after 3 doses of vaccine, with the last dose given when the pups were 14 to 16 weeks old. Maternally derived antibody was the primary cause of vaccination failure.
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Search related cases →Original publication on Crossref: https://doi.org/10.2460/javma.1986.188.07.699