Peer-reviewed veterinary case report
Ifosfamide chemotherapy results for cats with vaccine sarcomas
By Rassnick, Kenneth M et al.·Published in American journal of veterinary research·2006·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomas.
- Species:
- cat
Plain-English summary
A group of 27 cats with vaccine-associated sarcomas (a type of cancer that can occur at vaccination sites) received a chemotherapy drug called ifosfamide to see if it could help shrink their tumors. After treatment, 1 cat had no detectable cancer and 10 others showed some improvement, with responses lasting from about 3 weeks to over 4 months. While most cats tolerated the treatment well, some experienced side effects like low white blood cell counts and gastrointestinal issues. Overall, ifosfamide showed promise as a treatment option for this type of cancer in cats.
People also search for: cat vaccine-associated sarcoma treatment · ifosfamide for cats · cat cancer chemotherapy side effects
Abstract
OBJECTIVE: To determine clinical activity and toxic effects of ifosfamide when used to treat cats with vaccine-associated sarcoma (VAS). ANIMALS: 27 cats with a nonresectable, recurrent, or metastatic VAS. PROCEDURE: Each cat received ifosfamide (900 mg/m(2) of body surface area) as an IV infusion during a 30-minute period. Diuresis by infusion of saline (0.9% NaCl) solution and administration of mesna were used to prevent urothelial toxicosis. Treatments were administered every 3 weeks, and tumor response was assessed after the second treatment. All ifosfamide-associated toxic effects were graded in accordance with predetermined criteria. RESULTS: 61 treatments were administered to 27 cats (median, 2 treatments/cat; range, 1 to 4 treatments/cat). After ifosfamide treatment, 1 cat had a complete response and 10 had partial responses for an overall response rate of 11 of 27 (41%; 95% confidence interval [CI], 25% to 59%). Responses lasted from 21 to 133 days (median, 70 days; 95% CI, 60 to 113 days). The acute dose-limiting toxicosis was neutropenia, which was detected 5 to 28 days (median, 7 days) after treatment. Median nadir neutrophil count was 1,600 cells/muL (range, 200 to 5,382 cells/microL). Nine (33%) cats had adverse gastrointestinal effects (primarily salivation during the ifosfamide infusion and inappetence after treatment). Two cats were euthanatized because of severe nephrotoxicosis, and 1 cat developed pulmonary edema during diuresis. CONCLUSIONS AND CLINICAL RELEVANCE: Ifosfamide has antitumor activity against VAS in cats and is tolerated well by most cats. Ifosfamide should be evaluated as an adjuvant treatment for cats with VAS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16506920/