Peer-reviewed veterinary case report
Resveratrol helps canine oral melanoma cells become more like normal
By Fukuoka, Nana et al.·Published in The Journal of veterinary medical science·2023·Graduate School of Food and Nutritional Sciences, Japan·View original on PubMed →
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Original publication title: Resveratrol can induce differentiating phenotypes in canine oral mucosal melanoma cells.
- Species:
- dog
Plain-English summary
A study found that resveratrol, a compound found in grapes, can help treat oral mucosal melanoma (a type of cancer in dogs) by encouraging cancer cells to behave more like normal melanocytes (skin pigment cells). When canine oral melanoma cells were exposed to resveratrol for 72 hours, they showed signs of differentiation and became more sensitive to chemotherapy with cisplatin, although resveratrol alone did not kill the cancer cells. This suggests that resveratrol could be a helpful addition to treatment plans for dogs with this type of cancer, potentially improving the effectiveness of other therapies.
People also search for: dog oral melanoma treatment · resveratrol for dog cancer · canine melanoma chemotherapy
Abstract
This report described the differentiation induction of canine oral mucosal melanoma (OMM) cells by resveratrol. Exposure of canine OMM cells to resveratrol (maximum dose: 50 μM and treatment period: 72 hr) induced differentiating features like melanocytes, and enhanced chemosensitivity against cisplatin, but alone had no influence on cell viability. Additionally, resveratrol significantly enhanced mRNA expression of key melanoma differentiation markers such as microphthalmia-associated transcription factor (MITF). Of several inhibitors against mitogen-activated protein kinase subtypes, only the c-Jun N-terminal kinase (JNK) inhibitor, SP600125, induced melanocyte-like morphological change and enhanced MITF mRNA expression. Furthermore, resveratrol also suppressed JNK activation in OMM cells by approximately 33%. Overall, these findings suggest that resveratrol induces differentiation in canine OMM cells, due to the inhibition of JNK signaling.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37225449/