Peer-reviewed veterinary case report
Using PET/CT scans to find lymph node spread in dogs with bone cancer
By Slinkard, Powell T et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2021·College of Veterinary Medicine and Biomedical Sciences (CVMBS) (Slinkard) and Department of Environmental and Radiological Health Sciences (ERHS) (Randall, United States·View original on PubMed →
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Original publication title: Retrospective analysis of use of fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) for detection of metastatic lymph nodes in dogs diagnosed with appendicular osteosarcoma.
- Species:
- dog
Plain-English summary
A group of dogs with appendicular osteosarcoma (a type of bone cancer) underwent a special imaging test called F-FDG PET/CT to check for cancer spread to lymph nodes. Out of 77 lymph nodes sampled, only 3 were confirmed to have cancer. The study found that the imaging could help distinguish between cancerous and non-cancerous lymph nodes based on specific measurements. While the results are encouraging, more research is needed to confirm these findings and improve staging for dogs with this condition.
People also search for: dog bone cancer treatment · appendicular osteosarcoma in dogs · lymph node cancer in dogs
Abstract
The purpose of this retrospective analysis was to determine if fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography (F-FDG PET/CT) could potentially be an accurate staging tool for detecting metastatic lymph nodes in dogs with appendicular osteosarcoma based on the quantitative measurement of the maximum standard uptake value (SUV) of lymph nodes. A total of 53 dogs were identified that presented for stagingF-FDG PET/CT for primary appendicular osteosarcoma. Patients were categorized according to lymph node status of having either metastatic or non-metastatic nodes based on cytological or histological analysis. Maximum standard uptake (SUV) values of the sampled lymph node(s) were recorded and 3/77 (3.9%) of sampled lymph nodes were confirmed metastatic. A Mann-Whitney test revealed a statistical difference in the SUVof the metastaticnon-metastatic lymph nodes [median: 6.6 to 95% confidence interval (CI): 2.56 to 14.372.18 95% CI: 2.32 to 3.17, respectively,-value = 0.05]. This retrospective analysis revealed a significant difference in the SUVas measured onF-FDG PET/CT between metastatic lymph nodes and non-metastatic lymph nodes in canine patients afflicted with appendicular osteosarcoma, in spite of the small numbers analyzed. While these results are promising, they should be interpreted with caution and further studies are justified.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33883821/