Peer-reviewed veterinary case report
Comparing 3 doses of chlorambucil for cancer in dogs and side effects
By Custead, M R et al.·Published in Veterinary and comparative oncology·2017·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Retrospective comparison of three doses of metronomic chlorambucil for tolerability and efficacy in dogs with spontaneous cancer.
- Species:
- dog
Plain-English summary
A group of dogs with cancer were treated with different low doses of a medication called chlorambucil to see which dose worked best with the fewest side effects. The study found that while higher doses (6 mg and 8 mg) did not improve treatment outcomes, they caused more severe gastrointestinal issues and other side effects compared to the lower dose (4 mg). Dogs on the higher doses had to stop treatment sooner due to these problems. Overall, the lower dose was better tolerated and did not lead to worse outcomes.
People also search for: dog cancer treatment chlorambucil · side effects of chlorambucil in dogs · dog cancer medication dosage
Abstract
The study hypothesis is that higher doses of metronomic (low-dose) chlorambucil will improve outcome without significantly worsening adverse events (AE). Retrospectively, 88 dogs were screened to assess for tolerability and response to chlorambucil utilizing retrospective and prospective data sets, comparing metronomic oral daily doses 4, 6 and 8 mg m. There were 78 and 70 dogs in the tolerability and efficacy portions, respectively. The severity of gastrointestinal (GI) AE was significantly worse, and time to development of GI events was significantly shorter at 6 mg mthan at 4 mg m(both P < 0.001). Chlorambucil was discontinued earlier in the dogs treated at the 6 mg mdoses than in the dogs treated at 4 mg m(P = 0.015). Thrombocytopenia occurred significantly earlier at 8 mg mthan at 4 mg m(P = 0.017). Higher doses of metronomic (low-dose) chlorambucil did not provide improved responses and were associated with more AE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27136377/