Peer-reviewed veterinary case report
Retrospective evaluation of blood copper stable isotopes ratioCu/Cu as a biomarker of cancer in dogs.
- Journal:
- Veterinary and comparative oncology
- Year:
- 2017
- Authors:
- Chamel, G et al.
- Affiliation:
- Department of Internal Medicine · France
- Species:
- dog
Abstract
Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated with a modification of the blood ratio betweenCu andCu (∂Cu). The aim of the present study was to compare the blood ∂Cu of dogs with cancer to healthy controls or dogs with non-oncologic disease. One hundred and seventeen dogs were included in the study (35 dogs with cancer, 33 dogs with non-neoplastic disease, and 49 healthy controls). The ∂Cu of dogs with cancer was significantly lower than the ratio of healthy controls (P < 0.0001) but not significantly different from dogs with non-oncologic disease. Six dogs with lymphoma were also evaluated after they achieved clinical remission and five out of six had an increase of ∂Cu. Further studies are warranted but these results suggest that ∂Cu could help in the diagnosis of cancer in a controlled clinical context, and may be a potential biomarker for the follow-up of cancer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27714906/