Peer-reviewed veterinary case report
Cat nasal cancer treated with external beam radiotherapy outcomes
By Yoshikawa, Hiroto et al.·Published in Journal of veterinary internal medicine·2021·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Retrospective evaluation of intranasal carcinomas in cats treated with external-beam radiotherapy: 42 cases.
- Species:
- cat
Plain-English summary
A group of 42 cats with intranasal carcinomas (a type of nose cancer) received different types of radiation therapy to treat their condition. Those who underwent definitive treatments, like stereotactic or fractionated radiation, lived significantly longer and had better outcomes compared to those who received palliative care. On average, cats treated with definitive radiation survived about 721 days, while those with palliative treatment only survived around 284 days. If the cancer returned, cats that received a second round of definitive radiation therapy lived even longer, averaging 824 days.
People also search for: cat nose cancer treatment · radiation therapy for cats · intranasal carcinoma prognosis in cats
Abstract
BACKGROUND: Little is known regarding the comparative efficacy of various irradiation strategies used to treat intranasal carcinomas (INC) in cats. OBJECTIVES: Investigate outcomes and prognostic factors associated with survival for cats with INC. ANIMALS: Forty-two cats with INC that underwent radiotherapy (RT). METHODS: Single-arm retrospective study. Medical record review for cats with INC that underwent RT at 1 of 7 veterinary RT facilities. Irradiation protocols categorized as: definitive-intent fractionated RT (FRT), definitive-intent stereotactic RT (SRT), and palliative-intent RT (PRT). Median overall survival time (OST) and disease progression-free survival (PFS; documented by advanced transverse imaging, or recurrence of symptoms) were calculated. Associations between tumor stage, RT protocol/intent, and adjunctive treatment usage and outcome were calculated. RESULTS: Cats underwent SRT (N = 18), FRT (N = 8), and PRT (N = 16). In multivariate modeling, cats received definitive-intent treatment (DRT; FRT/SRT) had significantly longer median PFS (504 days, [95% confidence interval (CI): 428-580 days] vs PRT 198 days [95% CI: 62-334 days]; p = 0.006) and median OST [721 days (95% CI: 527-915 days) vs 284 days (95% CI: 0-570 days); p = 0.001]). Cats that underwent second DRT course at time of recurrence lived significantly longer than cats that received 1 RT course (either DRT or PRT [median OST 824 days (95% CI: 237-1410 days) vs 434 days (95% CI: 277-591 days); p = .028]). CONCLUSION: In cats with INC, DRT is associated with prolonged OST and PFS as compared to PRT. If tumor progression occurs, a second course of DRT should be considered.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33660305/