Peer-reviewed veterinary case report
High blood lactate linked to lymphoma in some dogs
By Touret, Maude et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2012·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Retrospective evaluation of potential causes associated with clinically relevant hyperlactatemia in dogs with lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with lymphoma was evaluated for high blood lactate levels, which can indicate serious health issues. Out of the dogs studied, 40% had elevated lactate levels, and only 10% of those were directly related to their cancer. Many of the dogs also showed signs of other health problems, and it was found that the use of corticosteroids was linked to higher lactate levels. Tests showed liver changes in all dogs with elevated lactate. This suggests that lymphoma alone might not be the only reason for high lactate levels in dogs.
People also search for: dog lymphoma symptoms · high blood lactate in dogs · corticosteroids and dog health · liver problems in dogs · dog cancer treatment options
Abstract
The aim of this study was to determine whether or not canine lymphoma could be associated with a clinically relevant type B hyperlactatemia (> 2.5 mmol/L). The medical database from the University of Montreal Veterinary Medical Teaching Hospital was searched for confirmed cases of canine lymphoma with a blood lactate measurement. Information retrieved included stage, clinical observations compatible with causes of type A and B hyperlactatemia other than cancer, hepatic involvement, and drugs administered. Twenty (40%) dogs were hyperlactatemic. Five dogs (10%) were classified as having cancer-related hyperlactatemia. Seventy-five percent of hyperlactatemic dogs had clinical evidence of type A hyperlactatemia. In addition to lymphoma, 70% of hyperlactatemic dogs had evidence of an additional cause of type B hyperlactatemia. A significant association (P = 0.01) was identified between corticosteroid administration and hyperlactatemia. Cytological, echographic, and/or biochemical tests revealed hepatic changes in all hyperlactatemic dogs. Lymphoma alone may not be sufficient to explain clinically relevant hyperlactatemia in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23115363/