Peer-reviewed veterinary case report
Risk factors for kidney injury in dogs treated with furosemide
By Giorgi, Maria E et al.·Published in Journal of veterinary internal medicine·2022·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Retrospective evaluation of risk factors for development of kidney injury after parenteral furosemide treatment of left-sided congestive heart failure in dogs.
- Species:
- dog
Plain-English summary
A group of 79 dogs with left-sided congestive heart failure (CHF) were treated with furosemide, a common diuretic, and nearly half developed kidney injury during their hospital stay. The kidney injury was mostly mild (Grade I) and did not affect the long-term survival of the dogs. Higher blood pressure during treatment was linked to a greater risk of kidney injury, while the amount of furosemide given after leaving the hospital also played a role. Fortunately, many dogs with more severe kidney injury showed improvement, and some lived for over a year after their condition.
People also search for: dog kidney injury furosemide treatment · congestive heart failure dog symptoms · furosemide side effects in dogs
Abstract
BACKGROUND: Kidney injury (KI) has been documented in dogs treated with furosemide for left-sided congestive heart failure (CHF). HYPOTHESIS/OBJECTIVES: Determine risk factors for development of KI in furosemide-treated dogs and determine the effect of KI on survival. ANIMALS: Seventy-nine client-owned dogs receiving parenteral furosemide for CHF. METHODS: Serum creatinine (sCr) and electrolyte concentrations were determined during hospitalization and at first outpatient reevaluation to detect and stage KI (increase in sCr ≥0.3 mg/dL). Furosemide dosage administered between timepoints was calculated. Multivariable modeling was performed to identify predictors of KI and percent change in serum biochemistry results over time. RESULTS: Kidney injury was identified in 38/79 (48%) dogs and mostly occurred during hospitalization. Kidney injury was Grade I in 25 dogs, Grade II in 9 dogs, and Grade III in 4 dogs. Higher blood pressure was associated with acute KI during hospitalization (odds ratio, 1.03; 95% confidence interval [95% CI] 1.01-1.07; P = .03) whereas PO furosemide dosage was associated with KI after hospital discharge (odds ratio, 7.77; 95% CI, 2.05-68.6; P = .02). Baseline sCr and use of a furosemide continuous rate infusion were not associated with increased risk of KI. Kidney injury was not associated with long-term outcome. Of 13 dogs with Grade II-III KI, azotemia was reversible in 9 dogs, and 6 dogs survived >1 year after KI. CONCLUSIONS AND CLINICAL IMPORTANCE: In this cohort of dogs receiving parenteral furosemide for CHF, KI was common, mostly nonazotemic (Grade I), and did not impact survival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36254646/