Peer-reviewed veterinary case report
Cryosupernatant transfusion to treat bleeding in dogs from rat poison
By Tracy, Alyx L et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2026·Charleston Veterinary Referral Center, United States·View original on PubMed →
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Original publication title: Retrospective Evaluation of Treatment of Coagulopathy Secondary to Suspected Vitamin K Antagonist Rodenticide Intoxication With Cryosupernatant Transfusion in Seven Dogs (2000-2017).
- Species:
- dog
Plain-English summary
A 3-year-old dog was brought to the vet with bleeding issues after suspected poisoning from a rodenticide that affects blood clotting. The dog received a transfusion of cryosupernatant, a blood product that helps with clotting, along with vitamin K injections. After treatment, the dog's bleeding improved significantly, and six out of seven dogs in the study were able to go home healthy. Unfortunately, one dog had to be euthanized due to severe organ failure. Overall, the transfusion helped many dogs recover from their bleeding problems.
People also search for: dog bleeding after rat poison · vitamin K treatment for dogs · cryosupernatant transfusion for dogs
Abstract
OBJECTIVE: To report the use of cryosupernatant (CS) transfusion for the treatment of suspected vitamin K antagonist rodenticide (VKAR)-associated coagulopathy in dogs and its impact on coagulation times. DESIGN: Retrospective case series (2000-2017). SETTING: University teaching hospital. ANIMALS: Seven dogs with hemorrhage associated with suspected VKAR intoxication treated with CS transfusion. INTERVENTIONS: CS transfusion. MEASUREMENTS AND MAIN RESULTS: The median age was 3.0 years, with a median weight of 17.7 kg. Initial coagulation testing revealed median one-stage prothrombin time and activated partial thromboplastin time of 697% and 393%, respectively, above control/average of the reference range (CARR). The median dose of CS was 11.0 mL/kg. One-stage prothrombin time decreased (p = 0.043) after CS transfusion to a median of 98% of CARR. Activated partial thromboplastin time (n = 3) decreased to 114% of CARR (sample size precluded statistical analysis) upon recheck. All dogs received vitamin K supplementation, with an initial median subcutaneous dose of 4.11 mg/kg. Initial median PCV and total plasma protein concentration were 27.0% and 4.5 g/dL (45 g/L), respectively, with posttransfusion PCV and total plasma protein concentration of 22.0% and 4.9 g/dL, respectively. Six dogs showed resolution of observed clinical hemorrhage and were discharged. One dog was euthanized due to multi-organ dysfunction. No transfusion reactions were reported. CONCLUSIONS: Dogs with suspected VKAR intoxication showed resolution of clinical hemorrhage after CS transfusion. Compared with fresh frozen plasma, CS is an option for treating VKAR-associated coagulopathy, despite lower factor IX activity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41582894/