Peer-reviewed veterinary case report
Dog with stage III mouth cancer improved by anti-PD-1 antibody
By Shuo Xu et al.·Published in Frontiers in Veterinary Science·2023·College of Veterinary Medicine, China Agricultural University, Beijing, China, CH·View original on DOAJ →
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Original publication title: Reversing stage III oral adenocarcinoma in a dog treated with anti-canine PD-1 therapeutic antibody: a case report
- Species:
- dog
Plain-English summary
An 11-year-old male border collie was brought in for a swollen mass on the left side of his neck. Tests showed that he had stage III oral adenocarcinoma, a type of cancer affecting the salivary glands. The dog was treated with a special antibody that targets cancer cells, and after two months, the tumor showed signs of shrinking. He maintained this improvement for six months before being euthanized for unrelated health issues, living a total of 316 days after starting treatment. This case highlights a promising new approach to treating canine cancer.
People also search for: dog neck mass treatment · border collie oral cancer · PD-1 antibody for dogs
Abstract
Monoclonal antibody targeting programmed cell death-1 (PD-1) is one of the most promising treatment therapies for human cancers. Canine PD-1 antibodies used in clinical trials have also shown efficacy in treating canine cancers. An 11-year-old male intact border collie presented to us for evaluation of left cervical mass. Computed tomography (CT) examination revealed an irregular pharyngeal mass invading the surrounding soft tissue. Histological and immunohistochemical results were consistent with a diagnosis of adenocarcinoma, most likely originating from the minor salivary gland. An anti-canine PD-1 monoclonal antibody was administered. Two months after the initial treatment, the tumor reached partial remission and maintained as such for 6 months. Finally, the patient was euthanized due to reasons unrelated to cancer, with a survival time of 316 days. To our knowledge, this is the first report of response to PD-1 blockade treatment in canine adenocarcinoma.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2023.1144869