Peer-reviewed veterinary case report
Parvo virus in dogs in Sri Lanka - risks and survival factors
By Gamage, B G S S et al.·Published in Comparative immunology, microbiology and infectious diseases·2020·Faculty of Veterinary Medicine and Animal Science·View original on PubMed →
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Original publication title: Risk, prognosis and causality of parvo viral enteritis in dogs in Sri Lanka.
- Species:
- dog
Plain-English summary
A study found that many dogs in Sri Lanka with parvovirus (a serious viral infection causing severe diarrhea) were vaccinated but still got sick. Puppies younger than 6 months and certain breeds like Dobermans and Labradors had a harder time surviving the illness. Most of the affected dogs had low white blood cell counts, which is a sign of a weakened immune system. The researchers identified different strains of the virus, with one strain being the most common. This highlights the importance of vaccination and monitoring young dogs for symptoms of parvovirus.
People also search for: dog parvo symptoms · puppy diarrhea treatment · vaccinated dog gets parvo · Doberman parvo survival rate
Abstract
We studied the causal variation, prognosis and risk factors of parvo viral enteritis using both molecular and statistical analysis. A multivariate factor analysis was performed to see the effect of the breed, age, vaccination status and the leukocyte counts on disease severity and survival. Twenty PCR amplicons (partial VP2 gene) from vaccinated dogs were sequenced to identify the variants. A total of 109 samples were positive for parvo viral DNA, 71 of which were from dogs who have received at least one dose of CPV-2 vaccine. Over 90% were leukopenic on 2and 3day of diarrhoea. Age < 6 months was negatively correlated with leukocyte count and the leukocyte count was negatively correlated with survival. Dobermans and Labradors showed significant negative correlation with survival. All variants of parvovirus affected dogs with the 2c being the predominant (2c = 12, 2a = 7, 2b = 1). All 20 strains harboured three additional amino acid substitutions (i.e. Phe267Tyr, Ser297Ala and Tyr324Ile) and warrant further studies on potential changes of the antigenicity of the virus.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32562954/