Peer-reviewed veterinary case report
RNA disruption test shows chemo success in dog lymphoma
By A. Parissenti et al.·Published in BMC Veterinary Research·2019·View original on Semantic Scholar →
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Original publication title: RNA disruption indicates CHOP therapy efficacy in canine lymphoma
- Species:
- dog
Plain-English summary
A 9-year-old Golden Retriever with lymphoma was treated with a chemotherapy protocol called CHOP, which includes several medications like cyclophosphamide and doxorubicin. During treatment, the vet monitored the dog's response by taking samples from lymph nodes and analyzing RNA disruption, which can indicate how well the cancer is responding. The results showed that higher RNA disruption scores were linked to better outcomes, meaning the dog had a longer time without the cancer worsening. This approach could help vets adjust treatment plans more effectively for dogs with lymphoma.
People also search for: dog lymphoma treatment · Golden Retriever cancer survival · CHOP chemotherapy for dogs
Abstract
BackgroundAssessment of the efficacy of a multi-agent chemotherapy protocol in which cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) are administered in canine lymphoma is generally performed by physical measurement of lymph node diameter. However, no consistent correlation has been made with prognostic indicators and the length or absence of clinical remission based on lymph node size. RNA disruption measured mid-therapy has been correlated with increased disease-free survival in recent studies of human cancer and was assessed in this study of canine lymphoma patients. Fine needle aspirate samples were taken before treatment and at weeks 3, 6, and 11 of CHOP therapy. RNA was isolated from these samples and assessed using an Agilent Bioanalyzer. RNA disruption assay (RDA) analysis was performed on the data from the resulting electropherograms.ResultsAn increased RNA disruption index (RDI) score was significantly associated with improved progression-free survival.ConclusionsPredicting the risk of early relapse during chemotherapy could benefit veterinary patients by reducing ineffective treatment and could allow veterinary oncologists to switch earlier to a more effective drug regimen.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/31842875