Peer-reviewed veterinary case report
Role of tumor necrosis factor alpha in development of immunity against Cryptosporidium parvum infection.
- Journal:
- Infection and immunity
- Year:
- 2006
- Authors:
- Lean, I-Sarah et al.
- Affiliation:
- Barts and the London School of Medicine · United Kingdom
- Species:
- rodent
Abstract
Tumor necrosis factor (TNF-alpha) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-alpha-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-alpha might have only a redundant role for establishing immunity against C. parvum.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16790816/