Peer-reviewed veterinary case report
Effects of SAMe on liver damage from acetaminophen in cats
By Webb, C B et al.·Published in Journal of feline medicine and surgery·2003·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury.
- Species:
- cat
Plain-English summary
A group of cats was given acetaminophen, which can cause liver damage, to see how S-adenosylmethionine (SAMe) might help. The cats treated with SAMe showed less damage to their red blood cells compared to those that only received acetaminophen. While there were some positive changes in blood tests, the results weren't strong enough to confirm that SAMe significantly improved liver health. However, it did seem to protect the red blood cells from damage. This suggests that SAMe could be a helpful treatment for cats suffering from acetaminophen toxicity.
People also search for: cat acetaminophen poisoning treatment · SAMe for cats liver health · feline oxidative injury symptoms
Abstract
S-adenosylmethionine (SAMe) is reported to have hepatoprotective and antioxidant functions. Acetaminophen (paracetamol) was used to induce oxidative damage in cats, and to then determine the effect of SAMe treatment on erythrocyte morphology, PCV, liver histopathology, thiobarbituate reacting substances (TBARS), reduced glutathione (GSH), and oxidised glutathione (GSSG). Cats receiving acetaminophen had a significant increase in methemoglobin and Heinz body production. A significant effect for the interaction of time and treatment was found for Heinz body production and changes in PCV. No significant changes were found in blood or hepatic TBARS. Blood GSH increased significantly in all cats, while the blood GSH:GSSG ratio tended to increase the most in cats given acetaminophen only. The hepatic GSH:GSSG ratio tended to increase in cats given SAMe and decrease in cats given acetaminophen, but this effect was not significant. SAMe protected erythrocytes from oxidative damage by limiting Heinz body formation and erythrocyte destruction and maybe useful in treating acetaminophen toxicity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12670431/