Peer-reviewed veterinary case report
Dog with skin lymphoma like human Sezary syndrome and mycosis
By Paz, Milena C et al.·Published in Journal of comparative pathology·2026·Setor de Patologia Veteriná, Brazil·View original on PubMed →
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Original publication title: Sézary syndrome arising from cutaneous epitheliotropic T-cell lymphoma, resembling human folliculotropic mycosis fungoides, in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old neutered male Pug was brought in due to ongoing skin issues, including thickened skin, red spots, and swollen lymph nodes. Tests showed an increase in certain white blood cells and identified cancerous cells in the skin and lymph nodes, leading to a diagnosis of Sèzary syndrome, a type of skin lymphoma. Unfortunately, despite the diagnosis, the dog's condition was severe, and he was euthanized. This case highlights the serious nature of skin-related cancers in dogs and the importance of early veterinary intervention.
People also search for: dog skin cancer symptoms · Pug with swollen lymph nodes · treatment for dog lymphoma
Abstract
A 9-year-old neutered male Pug dog presented with a history of chronic dermatitis. Dermatological examination revealed skin thickening with keratin fronds, erythematous macules and generalized lymphadenopathy. Haematology revealed leucocytosis with lymphocytosis and medium to large neoplastic lymphocytes having cerebriform nuclei (Sézary cells). Fine-needle aspirate samples from the skin and the superficial lymph nodes contained pleomorphic medium-sized lymphocytes and a cytological diagnosis of lymphoma was made. The dog was euthanized. In addition to the cutaneous lesions, post-mortem examination revealed lymphadenomegaly, splenomegaly and hepatomegaly. Histological examination of the skin revealed a neoplastic proliferation of large lymphocytes infiltrating the deep dermis and surrounding the hair follicles. Similar neoplastic cells were present in the lymph nodes, spleen, liver and bone marrow. Neoplastic cells were immunoreactive for CD3 and not for PAX-5. The final diagnosis was Sézary syndrome arising from cutaneous epitheliotropic T-cell lymphoma resembling human folliculotropic mycosis fungoides.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41610469/