Peer-reviewed veterinary case report
Gold nanorod heat therapy is safe for treating dog tumors
By Schuh, Elizabeth M et al.·Published in BMC veterinary research·2017·Veterinary Cancer Group, United States·View original on PubMed →
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Original publication title: Safety and efficacy of targeted hyperthermia treatment utilizing gold nanorod therapy in spontaneous canine neoplasia.
- Species:
- dog
Plain-English summary
Seven dogs with cancer received a new treatment using gold nanorods to enhance hyperthermia therapy, which heats tumors to help destroy them. After the treatment, the dogs showed mild side effects, mostly local reactions to the laser used in the therapy. Encouragingly, all the dogs had stable disease, and some even experienced partial or complete remission of their tumors. This suggests that the gold nanorod therapy is safe and may be effective for treating canine cancer, but more research is needed to confirm these results and find out which dogs might benefit the most.
People also search for: dog cancer treatment · gold nanorod therapy for dogs · canine neoplasia remission · hyperthermia therapy for dogs
Abstract
BACKGROUND: Hyperthermia is an established anti-cancer treatment but is limited by tolerance of adjacent normal tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyperthermia treatment while sparing normal tissues. This therapy is well tolerated and has demonstrated anti-tumor effects in mouse models. The purpose of this phase 1 study was to establish the safety and observe the anti-tumor impact of gold NR enhanced (plasmonic) photothermal therapy (PPTT) in client owned canine patients diagnosed with spontaneous neoplasia. RESULTS: Seven dogs underwent gold NR administration and subsequent NIR PPTT. Side effects were mild and limited to local reactions to NIR laser. All of the dogs enrolled in the study experienced stable disease, partial remission or complete remission. The overall response rate (ORR) was 28.6% with partial or complete remission of tumors at study end. CONCLUSIONS: PPTT utilizing gold nanorod therapy can be safely administered to canine patients. Further studies are needed to determine the true efficacy in a larger population of canine cancer patients and to and identify those patients most likely to benefit from this therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28969639/