Peer-reviewed veterinary case report
Safety of cancer tissue vaccine treatment in dogs
By Crossley, Rachel A et al.·Published in Anticancer research·2019·Department of Pathobiology and Veterinary Science, United States·View original on PubMed →
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Original publication title: Safety Evaluation of Autologous Tissue Vaccine Cancer Immunotherapy in a Canine Model.
- Species:
- dog
Plain-English summary
A group of 93 dogs with various tumors received a new type of cancer treatment called autologous tissue vaccine, which uses their own tumor tissue to help their immune system fight the cancer. Most dogs tolerated the treatment well, with only a few experiencing mild side effects like low fever, swelling at the injection site, or tiredness, all of which went away on their own. This study shows that this immunotherapy is safe for dogs and could be a promising option for treating cancer in pets.
People also search for: dog cancer treatment options · autologous vaccine for dogs · side effects of cancer treatment in dogs
Abstract
BACKGROUND/AIM: Previous work in rodent models showed that an autologous tissue vaccine is both a safe and effective approach for treating cancer; however, as a translational step, safety must first be evaluated in a more clinically-relevant model. MATERIALS AND METHODS: An autologous immunotherapy produced from resected tumors, was evaluated in a clinically-relevant canine model to assess safety. Ninety-three dogs with spontaneously occurring tumors received vaccination with inactivated autologous tumor tissue combined with an adjuvant of particulate porcine small intestinal submucosa extracellular matrix (SIS-ECM). Patients were followed to assess the occurrence of adverse events, overall survival, and tumor recurrence and/or metastasis. RESULTS: A small number (12%) of patients experienced limited, mild pyrexia, injection site swelling, or lethargy, all resolving without clinical intervention. CONCLUSION: Autologous whole cell cancer immunotherapy can be used safely in the canine model of cancer and represents a safe approach for the treatment for cancer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30952708/