Peer-reviewed veterinary case report
Safety of spinal chemotherapy with cytosine arabinoside
By Genoni, S et al.·Published in Veterinary and comparative oncology·2016·Dick White Referrals, United Kingdom·View original on PubMed →
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Original publication title: Safety of intrathecal administration of cytosine arabinoside and methotrexate in dogs and cats.
Plain-English summary
A group of 112 dogs and 8 cats received a treatment involving a spinal injection of cytosine arabinoside, either alone or with methotrexate, to address issues related to brain or spinal cord diseases. One pet experienced a seizure during recovery from anesthesia but was successfully treated with diazepam. Overall, the study found that this type of injection is generally safe for both dogs and cats.
People also search for: dog seizure after anesthesia · cat brain disease treatment · cytosine arabinoside for pets
Abstract
The objective of the study was to retrospectively evaluate the short-term safety of intrathecal administration of cytosine arabinoside alone or in combination with methotrexate in dogs and cats. One hundred and twelve dogs and eight cats admitted between September 2008 and December 2013, diagnosed with suspected inflammatory (meningoencephalomyelitis of unknown aetiology) or neoplastic disease affecting brain or spinal cord and treated with an intrathecal administration of cytosine arabinoside alone or in combination with methotrexate were included in the study. Recorded information regarding possible adverse events during administration while recovering from anaesthesia and during hospitalization period were evaluated. The results showed that one patient developed generalized tonic-clonic seizure activity after administration of cytosine arabinoside and methotrexate during recovery from anaesthesia, however responded to intravenous administration of diazepam. On the base of our results we can conclude that intrathecal administration of cytosine arabinoside alone or in combination with methotrexate is a safe procedure in dogs and cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25041580/